ccRCC takes VHL/HIF inactivation as the molecular basis, forming a metabolic network characterised by enhanced sugar metabolism, lipid droplet/lipid remodelling, reprogramming of amino acid and one-carbon metabolism, and redox imbalance, and mutual traction with the immunosuppressive microenvironment, becoming a key driver of disease progression and treatment tolerance. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.