Specifically, we observed significantly reduced levels of DSPE (PE 18:0/18:0; PubChem Compound ID 447078), DSPS (PS18:0/18:0; PubChem Compound ID 9547096), and SPG (C17Sphinganine‐1‐phosphate; PubChem Compound ID 3247041) in human POAG compared to control (Table 1; Figure 2A). Here, AANAT is linked to open-angle glaucoma.