TF was collected using Schirmer strips and evaluated using mass spectrometry-based proteomics and label-free quantification.ResultsThe expression of 33 TF proteins involved in oxidative stress, clearance mechanism, cytoskeleton stability, and inflammation were altered in persons with MCI compared with controls (<i>p</i> ≤ 0.05).ConclusionsOur findings reveal that numerous cellular stress-related biomarker candidate proteins are upregulated or downregulated in the TF of persons with MCI, a condition that may increase the risk of developing AD or other memory disorder. The gene discussed is TF; the disease is Alzheimer disease.