In addition, Disease subgroup analysis highlighted a prominent reduction in the levels of TNF-α (WMD: − 0.20; 95% CI − 0.34 to − 0.05; I2 = 97.10%) and CRP (WMD: − 0.29; 95% CI − 0.56 to − 0.02; I2 = 74.13%) in asthma patients. The gene discussed is TNF; the disease is asthma.