Notably, these effects were observed only when MNX1 was ectopically expressed in fetal liver–derived hematopoietic cells, but not in adult bone marrow–derived hematopoietic cells, consistent with the pathogenesis of t(7;12)(q36;p13) AML, which occurs almost exclusively in the pediatric setting5. Here, MNX1 is linked to acute myeloid leukemia.