In colorectal cancer, PUS7 facilitates cancer cell migration through the HSP90/PUS7/LASP1 pathway, enhances proliferation via SIRT1 activating the Wnt/β-catenin pathway, and stimulates proliferation and invasion through the PI3K/AKT/mTOR signaling pathway16,30,31. This evidence concerns the gene SIRT1 and colorectal cancer.