In colorectal cancer, PUS7 facilitates cancer cell migration through the HSP90/PUS7/LASP1 pathway, enhances proliferation via SIRT1 activating the Wnt/β-catenin pathway, and stimulates proliferation and invasion through the PI3K/AKT/mTOR signaling pathway16,30,31. The gene discussed is PUS7; the disease is colorectal cancer.