Interleukin 8 (IL-8) (10 ng/mL recombinant human IL-8, 48 h) stimulates BSP mRNA and protein in human LNCaP and DU145 prostate adenocarcinoma (pAdC) cells.55 IL-11 (20 ng/mL) induces BSP gene expression in SaOs-2 (6 h) and rat ROS17/2.8 (12 h) cells via Tyr kinase, ERK1/2 and PI3K/Akt signalling,14,56 and enhanced CREB1, phospho-CREB1 and AP-1 (c-Fos, c-Jun) interactions.14 Here, CREB1 is linked to prostate adenocarcinoma.