Cancer cell proliferation is fundamental to tumour growth, metastasis and aggressiveness, influencing disease progression and treatment response.118 The effect of BSP on cancer cell proliferation has been examined using assays such as MTT, Alamar Blue, sulforhodamine B (SRB),119 cell counting kit-8 (CCK-8),120 and colony formation.121 BSP expression has been modified through microRNA (miRNA)-mediated conditional knockdown, small-interfering RNA (siRNA) silencing and CMV-BSP vector overexpression. Here, IBSP is linked to cancer.