IBSP and osteosarcoma: Rat BSP stimulates migration of melanoma M21 (5 μg/mL, 5–8 h),147 BAC MDA-MB-231 (20 μg/mL, 8 h),38 and UMR-106 rat osteosarcoma cells (0.5 μg/mL and 1 μg/mL, 5–8 h).147 Recombinant BSP (0.03 μg/mL, 18 h) stimulates NSCLC A-549 and CL1-5 migration,92 while lower concentrations (0.005 μg/mL and 0.01 μg/mL) are ineffective.