Mechanistically, BSP-induced proliferation may involve RGD-mediated interactions with integrins αv and αvβ5.122 While integrin αvβ3 does not appear essential in BSP-induced proliferation of BAC MDA-MB-231 or melanoma (MDA-MB-435 and LCC15-MB) cells,122 it may mediate proliferation in other cancers. The gene discussed is IBSP; the disease is cancer.