IBSP and cancer: Endogenous BSP levels also influence cancer cell motility: Overexpression stimulates the migration (8 h, 24 h, 48 h) and invasion (8 h, 24 h, ≤10 days) in BAC (MDA-MB-231, MDA-MB-231-BAG, MCF-7, Hs578t) cells18,38,125 and promotes PC-3 invasion (8 h).38 Conversely, BSP knockdown through siRNA and miRNA inhibits migration (24 h, 48 h)18,123,124 and invasion (24 h) in MDA-MB-231 and MCF-7.18 Short hairpin RNA (shRNA)-mediated BSP knockdown reduces NSCLC (A-549 and CL1-5) migration and invasion by ≥50% (18 h).92