P4HA1 and neoplasm: Our multiomics approach further revealed the downregulation of proline hydroxylation signaling, particularly involving P4HA1, a regulator that stabilizes HIF-1α by limiting its degradation.15 Conversely, HIF-1α is normally targeted for degradation under normoxia via proline hydroxylation,16 suggesting that LDHA inhibition may restore the hypoxic balance and reduce HIF-1α–mediated tumor adaptation.