High-glycolytic PDACs presented increased expression of hypoxia-related genes, which is consistent with previous reports linking hypoxia to immunosuppression, therapeutic resistance, and tumor plasticity.12 Independent of the question of whether hypoxia, a highly glycolytic phenotype, and immunosuppression are the cause or consequence of each other, our data revealed a link between hypoxia, the UPR, and the glycolytic state—high-glycolytic tumors exhibited activation of UPR pathways, which were reduced following LDHA inhibition. This evidence concerns the gene LDHA and neoplasm.