For the second highlighted SNP-pair, rs7431710–rs4858795, rs7431710 is located in the LEPR gene (leptin receptor), which is involved in energy homeostasis and body weight regulation, and rs4858795 is associated with the NPSR1 gene (neuropeptide S receptor 1), implicated in asthma susceptibility and immune regulation. This evidence concerns the gene NPSR1 and asthma.