HLA-DRB5 and type 1 diabetes mellitus: As shown in Fig. 4D, we identified a total of five networks, one of which is a main network consisting of 62 T1D susceptibility genes, mainly connected by T1D susceptibility genes such as HLA-DRB5, HLA-B, HLA-A, and HLA-DPB1, which have been validated by relevant studies.