GMCL1 and Reduced sperm motility: The role of GMCL1 in germ cell development appears to have been evolutionarily conserved as loss of GMCL1 expression in mice has been shown to cause defects in meiosis and spermiogenesis (Liebe et al., 2006), and altered GMCL1 expression was functionally associated with human asthenozoospermia (Liu et al., 2018).