Annual screening for microvacular complications should begin either 5 years after a CFRD diagnosis or from the time FH is first identified—whichever occurs first [71].• Dilated eye examination for retinopathy• Spot urine albumin:creatinine ratio for nephropathy• Sensory foot examination with testing for vibration with a tuning fork and for pressure with 10 g monofilament (peripheral neuropathy). The gene discussed is ALB; the disease is peripheral neuropathy.