• Long‐acting insulin analogs (e.g., detemir and glargine) are recommended, started in the early morning at 0.1 U/kg and titrated in 0.1 U/kg increments to a target of 0.25 U/kg/day.• The goal is to keep postprandial BGLs <140 mg/dL while minimizing hypoglycemia.• If fasting hypoglycemia before lunch (BGL <70 mg/dL) occurs, the basal dose may be split—two‐thirds in the morning, one‐third in the evening—with further adjustment based on glucose monitoring. This evidence concerns the gene INS and Hypoglycemia.