SLC7A11 and amyotrophic lateral sclerosis: System Xc- expression is upregulated in oligodendrocytes under oxidative stress and inflammatory conditions (Lewerenz et al., 2013)In ALS, SLC7A11 expression in mature oligodendrocytes is reduced, leading to axonal demyelination and excitotoxic death of motorneurons (Philips et al., 2013)