SLC7A11 and epilepsy: Under hypoxic conditions, astrocytes exhibit enhanced System Xc- activity, which increases glutamate release and contributes to excitotoxicity (Jackman et al., 2012)IL-1β upregulates SLC7A11 expression in astrocytes (Shi et al., 2016)Slc7a11 mRNA and protein levels are elevated in astrocytes in epilepsy models (Zhang et al., 2024; Alcoreza et al., 2021)