FAM107A and Anxiety: To test our hypothesis that the MR-mediated downregulation of Fam107a contributes to the male-specific increase in anxiety-related behavior, MRNex and Ctrl mice were injected in the CA3 region of the hippocampus with either a Fam107a-expressing virus AAV1/2-CAG-FAM107A-IRES-eGFP-WPRE-bGHp(A) or a Ctrl virus AAV1/2-CAG-IRES-eGFP-WPRE-bGHp(A) (Figure 4A).