Based on the proof of principle provided here for oAd-mediated dual-targeting TCEs, future work will have to explore the activity of the scDb-cMET- and taFv-EGFR-encoding Ad5/3-DMTtE and of the Db-TriTE scDb-cMET-scFv-EGFR-encoding Ad5/3-DMFE in heterogeneous primary tumor cultures and animal tumor models (for which, however, the Ad5/3-DMTtE should first be improved for better co-expression as discussed above). This evidence concerns the gene EGFR and neoplasm.