GRK2 and experimental autoimmune encephalomyelitis: In an experimental autoimmune encephalomyelitis (EAE) murine model of multiple sclerosis (MS), the premature onset of EAE in GRK2+/− mice was associated with increased CNS infiltration by T cells; GRK2+/− mice, however, did not relapse and overall had an attenuated inflammatory response compared to WT mice [36].