Notably, the patient had no family history of SCD or arrhythmia-related cardiac events, experienced VF for the first time only in the setting of STEMI at the age of 47, and had no episodes of acute ischemia events or SCD during follow-up, which supported the TTN missense variant as a subclinical pathogenic substrate for acquired arrhythmic syndrome. The gene discussed is TTN; the disease is ventricular fibrillation.