TP53 and cancer: Phenothiazinesare a class of chemical compounds that have longbeen used in medicine, mainly as antipsychotics and antihistamines. Recent studies suggest that some phenothiazinesmay have, in addition to other properties, significant anticanceractivity.−, , ,  Their mechanism of action following occurrence may be due to interactionwith p53, which plays a key role in secondary regulation and apoptosis.Phenothiazines may stimulate apoptosis in cancer cells by activatingp53-dependent pathways.