BCL2 is mainly responsible for the carcinogenesisof hematological malignancies. Duringthe RT-PCR experiment for the HCT116 line with mutated p53 proteinand the MJ1 and MJ2 compounds, an obvioussilencing of the expression level was observed, which means that thetested compounds inhibited the expression of this gene. The gene discussed is BCL2; the disease is hematologic disorder.