Blocking AIFM2,e.g., with specific inhibitors, is a potential therapeutic strategythat could increase the sensitivity of cancer cells to ferroptosisinduction. In turn, increasing AIFM2expression in cancer cells could contribute to the induction of celldeath via apoptosis. Further studieson AIFM2 may reveal new therapeutic targets for cancer and diseaseslinked to oxidative stress. Here, AIFM2 is linked to cancer.