The cytostatic effect of structural analogues of phenothiazines,in which benzene rings were replaced by azine systems (pyridines – BM1, BM2, and quinoline – MJ1, MJ2), on the HCT116 colon cancer cell line with wild-typep53 protein status and with mutated p53 protein, was studied. The gene discussed is TP53; the disease is malignant colon neoplasm.