They also reported that the compounds were weaker thantacrine against BChE but less toxic in silico and noted that semicarbazones likely have amore rigid or specific structure, allowing for stronger and more stableinteractions with ChEs. However, theselimited studies suggest that semicarbazones may have significant potentialin the development of more selective and effective drug candidatesfor the treatment of AD. Here, BCHE is linked to Alzheimer disease.