TRAF6 and rheumatoid arthritis: This may indicate that IRAK1and TRAF6 are regulated at other control levels or may respond differentlyto miR-146a depending on cytokine stimuli. In peripheral mononuclear cells of rheumatoid arthritis (RA) patients,miR-146a was found to be overexpressed, yet no change in IRAK1 andTRAF6 expression was observed.