RXFP1 and Hepatic fibrosis: ,22,23 In liver fibrosis models, relaxin protein interacts with relaxin/insulin-like family peptide receptor 1 (RXFP1), inhibits the release of inflammatory factors and activation of HSCs,24,25,26 reduces excessive ECM deposition,27 upregulates matrix metalloproteinase (MMP) expression,25,28 and promotes the degradation of fibrotic matrices,26 thereby achieving therapeutic effects against liver fibrosis.