While AOS has been linked to autosomal dominant and recessive mutations in multiple genes, including ARHGAP31, DLL4, NOTCH1, RBPJ, DOCK6, and EOGT, which converge on critical developmental pathways such as Notch signaling (essential for vascular and limb patterning) and Rho GTPase regulation (key for cytoskeletal dynamics and tissue morphogenesis), sporadic cases remain well documented [3,4]. Here, DOCK6 is linked to Adams-Oliver syndrome.