CARD9 and colitis: A wider polybiome contribution is highlighted by the fact that, in addition to bacteria, the intestinal mycobiome and host antifungal pathways, such as dectin-1/C-type lectin domain family 7 member A (CLEC7A)-caspase recruitment domain-containing protein 9 (CARD9) signaling, interact with innate immunity and can alter the severity of colitis [31-33].