β-hCG-secreting CRC are associated with lower survival rates and increased propensity for local invasion and metastasis compared with non-secreting tumors [6]. There is also a possibility of metastatic dedifferentiation of CRC into GCT-like morphology, leading to co-secretion of β-hCG and AFP [11]. Similar to trophoblastic tumors, β-hCG-secreting malignancies may demonstrate high chemosensitivity, with serum β-hCG levels decreasing markedly following treatment [9,13,14]. The gene discussed is AFP; the disease is colorectal carcinoma.