A 36-year-old woman with well-controlled systemic lupus erythematosus (SLE) and prior pulmonary tuberculosis (TB) developed fever, weight loss, anemia (hemoglobin 7.6 g/dL), thrombocytopenia (78,000/mm3), and elevated inflammatory markers (ESR 89 mm/hr, CRP 67 mg/L), with symptom onset five months earlier (Month 0). The gene discussed is CRP; the disease is pulmonary tuberculosis.