Specifically, research indicates that overexpression of uc.138 significantly enhances the proliferation of CRC cells, primarily by upregulating cell cycle-related genes such as CDK1, cyclin A, and cyclin B, while concurrently downregulating the cyclin-dependent kinase inhibitor p21 (CDKN1A), particularly during the G2 and S phases. Here, CDKN1A is linked to colorectal carcinoma.