Specifically, overexpression of uc.138 has been shown to downregulate genes associated with cell death, such as TP53, CASP2, CASP7, CASP9, RAS, BCL-XL, NFKB1 and so on, thereby reducing the sensitivity of cancer cells to chemotherapeutic agents such as 5-fluorouracil and doxorubicin. This evidence concerns the gene TP53 and cancer.