NLRP3 and type 2 diabetes mellitus: Although the mechanism link between oral pathogens and NLRP3 inflammasome activation is mainly supported by in vitro and animal studies, the newly emerging human clinical data on the analysis of the microbial composition in the saliva of patients with type 2 diabetes and healthy individuals show that specific oral pathogens are associated with the prognosis of patients with type 2 diabetes.