Both MFN2, a mitochondria protein regulating the structure and function of mitochondria, and OPA1, a protein regulating mitochondrial dynamics, are downregulated in hypertension, reducing mitochondrial fusion and compromising oxidative capacity.26,27 MFN2 loss in vascular smooth muscle cells (VSMCs) exacerbates ROS production and endothelial dysfunction. This evidence concerns the gene MFN2 and endothelial dysfunction.