Compounds such as trehalose, which is a natural disaccharide and resveratrol, a polyphenol, have been identified as TFEB activators.124 Trehalose elevates lysosomal biogenesis by inactivating mTORC1 and driving TFEB into the nucleus, thereby enhancing autophagy of dysfunctional proteins and organelles.125 Resveratrol likewise has been shown to stimulate TFEB and augment autophagic clearance in models of metabolic and neurodegenerative disease.124 Although studies specifically linking TFEB activation to blood pressure control are limited, the concept is gaining interest. This evidence concerns the gene TFEB and neurodegenerative disease.