MERCs regulate calcium transfer via voltage-dependent anion channel 1 (VDAC1) and inositol 1,4,5-trisphosphate receptor (IP3R), mediated by glucose-regulated protein 75 (GRP75).85,86 Aging disrupts this complex, leading to mitochondrial calcium overload and hypertension. This evidence concerns the gene VDAC1 and hypertensive disorder.