DNM1L and Encephalopathy: The inhibition of mitofusin (MFN)2 can have a positive impact on the elongation of peroxisomes independently of the mitochondrial network, suggesting the regulation of MFN2 via activators and inhibitors to determine the role of peroxisomes to the metabolic defects in EMPF1 encephalopathy patients.45 Knockdown of Drp1 in mice led to mitochondrial hyperfusion, impaired lipid metabolism, and accumulation of succinate, indicating a disruption in complex II activity.