To further demonstrate the interaction between AP1S1 and miR‐let‐7b‐5p, we overexpressed AP1S1 in macrophages and found that upon cotreatment with the A549‐Exo‐miR‐let‐7b‐5p mimic, AP1S1‐OE significantly counteracted the tumor‐suppressive effects of lung cancer exosomal miR‐let‐7b‐5p (Figure 7d). This evidence concerns the gene AP1S1 and neoplasm.