Notably, LAP3 showed the strongest association with ANA (r = 0.54798, p = 0.00172), IFI44L with Ro/SSA (r = 0.83312, p = 1.11e − 08), and IFI44 with La/SSB (r = 0.70709, p = 2.59e − 05) (Table 2), reinforcing their clinical relevance in SS diagnosis and disease activity assessment. The gene discussed is CALR; the disease is synovial sarcoma.