Guanylate binding protein 2 (GBP2) was identified as the downstream factor of ZFP36 by bulk sequencing and RNA immunoprecipitation, which disturbed the YAP1 (yes-associated protein 1)/TEAD1 (TEA domain transcription factor 1) signaling and promoted VSMC dysfunction and AAA progression. Here, ZFP36 is linked to triple-A syndrome.