To examine the potential role of ZFP36 in AAA progression, we constructed VSMC-specific Zfp36-deficient mice (Zfp36△SMC) and the littermate control mice (Zfp36flox/flox) (Fig. S1A to G) and established an AAA model following a previous reported protocol [15]. This evidence concerns the gene ZFP36 and triple-A syndrome.