The pathological misfolding and aggregation of α-synuclein (α-Syn) are fundamental mechanisms in the onset of several neurodegenerative diseases, including Parkinson’s disease (PD), dementia with Lewy bodies (DLB), Parkinson’s disease dementia (PDD), and multiple system atrophy (MSA), collectively known as synucleinopathies [[1], [2], [3], [4]]. This evidence concerns the gene SNCA and multiple system atrophy.