For example, CRAMP-deficient mice are hypersusceptible to: necrotizing skin infection caused by Streptococcus pyogenes [13]; keratitis [14] and pneumonia [15] caused by Pseudomonas aeruginosa; pneumonia caused by Klebsiella pneumoniae [16]; urinary tract infection caused by E. coli [17]; intestinal tract infection caused by Citrobacter rodentium [18]; mastitis caused by Staphylococcus aureus [19]; meningitis caused by Streptococcus pneumoniae [20]; and viral lung [21] and skin [22] infection by RSV and vaccinia virus, respectively. The gene discussed is CAMP; the disease is keratitis.