Guo et al. analyzed the EV surface proteins of patients with colorectal cancer (CRC) at single-EV resolution using PBA and found that integrin subunit beta 3 (ITGB3+) and integrin subunit alpha M (ITGAM+) EVs may be potential diagnostic, prognostic, and therapeutic biomarkers for CRC[14]. Here, ITGAM is linked to colorectal cancer.