The results demonstrated that treatment of exosomes from H446-OE and HUVEC-OE cells markedly decreased the expression level of miR-204-5p [Figure 5A and B] and increased PFN2 expression in three wild-type SCLC cells (H446, H196 and DMS114 cells), compared to controls treated with H446-OC or HUVEC-OC exosomes by qRT-PCR [Figure 5C-F] and Western blot [Figure 5G and H]. Here, PFN2 is linked to small cell lung carcinoma.