To explore the functional role of exosomal LYPLAL1-DT in SCLC progression, we treated various SCLC cell lines, wild-type H446 cells (H446-WT), wild-type DMS114 cells (DMS114-WT) and LYPLAL1-DT knockdown H196 cell lines (referred to as shRNA-1, -2 and -3-H196 cells) with exosomes derived from H446-OE and H446-OC cells to investigate their effects on cell proliferation, migration, and invasion. The gene discussed is LYPLAL1; the disease is small cell lung carcinoma.