(2020) developed a noninvasive model based on laminin, procollagen III N-terminal peptide, and platelet count, which achieved an AUC of 0.765 for predicting significant fibrosis in Chinese patients with chronic hepatitis B. Notably, despite relying on specialized biochemical markers, the discriminative ability of their model was still lower than that of ours. The gene discussed is LAMB2; the disease is chronic hepatitis B virus infection.