(2013) for chronic hepatitis C patients included variables such as hyaluronic acid, TGF-β1, α2-macroglobulin, Matrix Metalloproteinase (MMP)-2, apolipoprotein-A1, urea, MMP-1, alpha-fetoprotein, haptoglobin, red blood cell count, hemoglobin, and TIMP-1. This evidence concerns the gene MMP1 and chronic hepatitis C virus infection.