Lymphopenia is specifically characterized by increased T cell apoptosis and inhibition of the IL-2 signaling pathway (Cantini et al., 2019; Nesreen, Marwa & Asmaa, 2020), leading to a decrease in TB specific CD4+T cell response ability (Ibrahim, Sani & Timothy, 2016; Scolnik et al., 2014), increasing the susceptibility of SLE patients to TB infection. The gene discussed is IL2; the disease is systemic lupus erythematosus.