Furthermore, analysis of TCGA glioma datasets revealed significant positive correlations between ASPHD1 expression and neuronal differentiation markers, including ENO2, MAP2, TUBB3, RBFOX3, SYP and NeuroD1 (Figures 10C–H), supporting the clinical relevance of ASPHD1 in promoting neuronal lineage commitment in gliomas. This evidence concerns the gene SYP and central nervous system cancer.