Multivariate regression analysis indicated that low ASPHD1 expression (hazard ratio, 0.999; 95% confidence interval, 0.997–1.000, P < 0.05), older age (hazard ratio, 1.060; 95% confidence interval, 1.027–1.093, P < 0.001) and higher grade (P < 0.001) were independent risk factors of gliomas (Table 3). This evidence concerns the gene ASPHD1 and central nervous system cancer.