ASPHD1 and central nervous system cancer: ASPHD1 expression showed modest but significant ability to distinguish glioma from normal brain tissue, with areas under the curve (AUCs) of 0.646 in the TCGA cohort, 0.710 in the CGGA mRNAseq_325 cohort, and 0.641 in the CGGA mRNAseq_693 cohort (Figure 2B).