Furthermore, analysis of TCGA glioma datasets revealed significant positive correlations between ASPHD1 expression and neuronal differentiation markers, including ENO2, MAP2, TUBB3, RBFOX3, SYP and NeuroD1 (Figures 10C–H), supporting the clinical relevance of ASPHD1 in promoting neuronal lineage commitment in gliomas. Here, ENO2 is linked to central nervous system cancer.