ASPHD1 and central nervous system cancer: Multivariate regression analysis indicated that low expression of ASPHD1 (hazard ratio, 0.989; 95% confidence interval, 0.978–0.999, P < 0.05), older age (hazard ratio, 1.016; 95% confidence interval, 1.003–1.030, P < 0.05), higher grade of glioma, absence of the 1p19q co-deletion (hazard ratio, 0.279; 95% confidence interval, 0.163–0.477, P < 0.001), whether recurrence(hazard ratio, 2.593; 95% confidence interval, 1.903–3.533, P < 0.001) are independent risk factors (Table 5).