Typical and common molecular alterations in glioma include isocitrate dehydrogenase (IDH) mutations, 1p/19q codeletion, TP53 mutations, Phosphatase and Tensin Homolog(PTEN) loss, epidermal growth factor receptor (EGFR) amplification and O6-methylguanine DNA methyltransferase (MGMT) promoter methylation. The gene discussed is TP53; the disease is central nervous system cancer.