Further studies have shown that HIF-1α in hepatocellular carcinoma activates the Akt/mTOR/STAT3 signaling pathway through IL-8 (95), and HIF-1α in colorectal cancer reduces E-cadherin and increases vimentin through increased activity of zinc finger E-box 1 (ZEB1), thus promoting epithelial–mesenchymal transition, tumor cell migration, and invasion (96). This evidence concerns the gene HIF1A and neoplasm.