ACSS2 and neoplasm: After glucose deprivation, acetyl-CoA synthetase 2 (ACSS2) enters the nucleus, binds to the transcription factor EB, and converts the acetate produced by the deacetylation of histone or other nucleoproteins into acetyl-CoA, which is used for histone acetylation in the promoter region of lysosome and autophagosome genes, thus enhancing autophagy and lysosome biosynthesis to maintain intracellular homeostasis during tumor growth (105).