IL1A and breast cancer: found that both the upregulation and inhibition of SRPK1 might increase AKT signaling by disrupting phosphatase regulation (71), and breast cancer RNA-seq revealed approximately 187 DEGs, with enrichment for NF-κB signaling-related transcripts (IL1A, IL1B, TRAF3, RELB), indicating a function for SRPK1 in controlling inflammation and migration via transcription regulation (45).