Also, monocyte-derived DCs (MDDCs) obtained from AD patients, likewise MDDCs from healthy donors generated in the presence of the amyloid beta peptide (Aβ), have impaired antigen presenting activity and enhanced pro-inflammatory functions (31, 32), while circulating myeloid DC precursors of AD patients are decreased in relation to disease progression (33). The gene discussed is APP; the disease is Alzheimer disease.