To further support the observations obtained in tumors and to evaluate the role of miR-99b, miR-125a and let-7e in melanoma cells, we assessed their expression levels and that of the host gene SPACA6 in a panel of six BRAFV600E-mutated melanoma cell lines with acquired resistance to BRAFi and BRAF/MEKi previously characterized in our laboratory (26). Here, SPACA6 is linked to melanoma.