Concomitant with the upregulation of SPACA6 levels, elevated expression of the miR-99b∼125a∼let-7e cluster was reported in liver cancer and esophageal squamous cell carcinomas, where it promoted tumor invasion and metastasis through regulation of ZEB1 activity (11, 12, 42). The gene discussed is SPACA6; the disease is esophageal squamous cell carcinoma.