TGFB1 and melanoma: We found that the upregulation of SPACA6 and of the hosted miRNAs in Treated vs Untreated tumor samples follows the same pattern as TGFB, CD274 (PDL1), and PDCD1LG2 (PDL2) genes (Figure 1D), thus suggesting a role for SPACA6-hosted miRNA cluster in the modulation of the TME, potentially influencing immune responses and therapeutic resistance in melanoma.