Neoplastic mast cells may impair hematopoiesis through the secretion of inhibitory cytokines such as tumor necrosis factor-alpha (TNF-α) and TGF-β, which negatively regulate HSCs proliferation and differentiation (45, 46), leading to pancytopenia and disruption across erythroid, myeloid, and lymphoid lineages. The gene discussed is TNF; the disease is Pancytopenia.