Pseudo-time analysis of gene expression demonstrates that JUN, a gene controlling cell cycle progression, is repressed in asthma patients while SPI1, an essential gene for lymphoid lineage development along with six inflammatory response related genes (S100A8, S100A9, S100A12, IL7R, IL32, and CCL5), exhibit various aberrant expression trajectories in asthmatic individuals. The gene discussed is S100A12; the disease is asthma.