Dysregulation of immune response characterizes the Pathogenesis of IBS, which compromises the intestinal epithelial barrier integrity, leading to chronic inflammation, by hypersecretion of pro-inflammatory mediators involving Tumor Necrosis factor-alpha(TNF-α) and Interleukin-6 (IL-6), which release by overactive T-helper-1 (Th1) and T-helper-17 (Th17) cells in CD or T-helper-2(Th2) cell in UC (14). This evidence concerns the gene IL6 and irritable bowel syndrome.