A targeted literature search was conducted in PubMed, Scopus, and Web of Science for all available years up to 2025, using Annexin-related terms (“Annexin A1”, “AnxA1”, “Annexin A2”, “AnxA2”) combined with inflammatory bowel disease terms (“inflammatory bowel disease”, “ulcerative colitis”, “Crohn* disease”, “colitis”). The gene discussed is ANXA2; the disease is colitis.