Annexin A1 (AnxA1) is a glucocorticoid-regulated protein that promotes inflammation resolution through multiple mechanisms, including inhibition of NF-κB signaling, enhancement of IL-10 production, limitation of neutrophil recruitment, and promotion of macrophage-mediated efferocytosis; these actions support mucosal healing in preclinical colitis models and are associated with mucosal recovery in human samples (9, 17, 18). Here, NFKB1 is linked to colitis.