Tumor cells evade immune surveillance by expressing immunosuppressive ligands that bind to inhibitory receptors on T cells, such as Programmed Cell Death Protein1 (PD-1), Lymphocyte activation gene 3 (LAG-3), T cell immunoglobulin and mucin domain 3 (TIM-3),T cell immunoglobulin and ITIM domain (TIGIT), V-domain lg suppressor of T cell activation (VISTA) and CD244, forming co-inhibitory molecules that suppress T cell function (6). This evidence concerns the gene LAG3 and neoplasm.