Specifically, silencing E-cadherin markedly reduces MST1/2 and LATS1/2 expression while significantly increasing YAP expression (33); deletion of α-catenin in mouse cardiomyocytes enhances nuclear YAP localization (29); Scribble suppresses YAP-induced pronephric cyst formation in zebrafish (30); and Crumbs functions as a tumor suppressor that activates the Hippo pathway by binding to Expanded (31). The gene discussed is YAP1; the disease is cyst.