In the HFD-induced obesity model in male mice, deletion of PAD4 in hematopoietic cells (Padi4KO) or pharmacologic inhibition of PADI4 by the selective PADI4 inhibitor GSK484 did not affect body weight gain or fat accumulation (39). The gene discussed is PADI4; the disease is obesity due to melanocortin 4 receptor deficiency.