For anxiety or depression, individual indices WBC, platelets, neutrophils, CRP, GlyA and composite indices NLR, SII, SIRI, INFLA all showed significant mediating effects, with intermediate ratios of 3.13, 1.85, 4.84, 6.68, 5.86, and 3.52%, 4.55, 4.06, 9.00%, respectively. The gene discussed is SHMT2; the disease is Anxiety.