For anxiety or depression, individual indices WBC, platelets, neutrophils, CRP, GlyA and composite indices NLR, SII, SIRI, INFLA all showed significant mediating effects, with intermediate ratios of 3.13, 1.85, 4.84, 6.68, 5.86, and 3.52%, 4.55, 4.06, 9.00%, respectively. This evidence concerns the gene CRP and Anxiety.